Drug interactions
Fluticasone-vilanterol + Lapatinib
Severity: Moderate
Fluticasone-vilanterol and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can prolong the QT interval and vilanterol may add to cardiac effects. Lapatinib also inhibits CYP3A4, which may raise exposure to inhaled fluticasone furoate and vilanterol.
What this interaction means in plain words
Fluticasone-vilanterol and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Lapatinib belongs to Oncology.
Why it happens
Additive QTc prolongation plus CYP3A4 inhibition by lapatinib.
What to do
Monitor ECG and electrolytes during lapatinib therapy and watch for beta-agonist and corticosteroid excess effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone-vilanterol and Lapatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluticasone-vilanterol
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Lapatinib?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib can prolong the QT interval and vilanterol may add to cardiac effects. Lapatinib also inhibits CYP3A4, which may raise exposure to inhaled fluticasone furoate and vilanterol.
How serious is the interaction between Fluticasone-vilanterol and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes during lapatinib therapy and watch for beta-agonist and corticosteroid excess effects.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
