Drug interactions
Fluticasone-vilanterol + Lenacapavir
Severity: Moderate
Fluticasone-vilanterol and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor with a long-lasting effect after subcutaneous dosing. It may raise exposure to fluticasone furoate and vilanterol, increasing systemic corticosteroid and beta-agonist effects.
What this interaction means in plain words
Fluticasone-vilanterol and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Lenacapavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 metabolism of fluticasone furoate and vilanterol.
What to do
Monitor for tachycardia, tremor, hypokalemia and features of systemic corticosteroid excess. Consider an alternative inhaled regimen if prolonged coadministration is expected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Lenacapavir?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor with a long-lasting effect after subcutaneous dosing. It may raise exposure to fluticasone furoate and vilanterol, increasing systemic corticosteroid and beta-agonist effects.
How serious is the interaction between Fluticasone-vilanterol and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tachycardia, tremor, hypokalemia and features of systemic corticosteroid excess. Consider an alternative inhaled regimen if prolonged coadministration is expected.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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