Drug interactions
Fluticasone-vilanterol + Levofloxacin
Severity: Moderate
Fluticasone-vilanterol and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin can prolong the QT interval and vilanterol may add to cardiac effects. The risk is small but increased with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Fluticasone-vilanterol and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive QTc prolongation with beta-agonist adrenergic and hypokalemic effects.
What to do
Correct potassium and magnesium and monitor ECG in at-risk patients. Consider a non-QT-prolonging antibiotic if there are other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Levofloxacin?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin can prolong the QT interval and vilanterol may add to cardiac effects. The risk is small but increased with electrolyte disturbance or cardiac disease.
How serious is the interaction between Fluticasone-vilanterol and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium and monitor ECG in at-risk patients. Consider a non-QT-prolonging antibiotic if there are other risk factors.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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