Drug interactions
Fluticasone-vilanterol + Maprotiline
Severity: Major
Fluticasone-vilanterol and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline, a tetracyclic antidepressant, can prolong QT and potentiate the cardiovascular effects of beta-agonists. Together they may increase tachycardia and arrhythmia risk.
What this interaction means in plain words
Fluticasone-vilanterol and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Noradrenaline reuptake inhibition and QTc prolongation add to beta2-agonist adrenergic stimulation.
What to do
Monitor heart rate, blood pressure and ECG, and consider alternative antidepressants in patients with cardiac disease.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Maprotiline?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Maprotiline, a tetracyclic antidepressant, can prolong QT and potentiate the cardiovascular effects of beta-agonists. Together they may increase tachycardia and arrhythmia risk.
How serious is the interaction between Fluticasone-vilanterol and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, and consider alternative antidepressants in patients with cardiac disease.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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