Drug interactions
Fluticasone-vilanterol + Mifepristone
Severity: Major
Fluticasone-vilanterol and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, particularly at the higher doses used for Cushing's syndrome, inhibits CYP3A4 and prolongs QT. This can raise fluticasone furoate and vilanterol exposure, increasing corticosteroid and cardiovascular effects.
What this interaction means in plain words
Fluticasone-vilanterol and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by mifepristone increases inhaled drug exposure, with additive QTc prolongation.
What to do
Avoid the combination where possible or use an alternative inhaler not dependent on CYP3A4. If combined, monitor ECG, potassium and signs of systemic corticosteroid excess.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Mifepristone?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone, particularly at the higher doses used for Cushing's syndrome, inhibits CYP3A4 and prolongs QT. This can raise fluticasone furoate and vilanterol exposure, increasing corticosteroid and cardiovascular effects.
How serious is the interaction between Fluticasone-vilanterol and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible or use an alternative inhaler not dependent on CYP3A4. If combined, monitor ECG, potassium and signs of systemic corticosteroid excess.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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