Drug interactions
Fluticasone-vilanterol + Mitotane
Severity: Moderate
Fluticasone-vilanterol and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a potent CYP3A4 inducer that can lower exposure to CYP3A4 substrates for weeks after it is stopped. Reduced levels of fluticasone furoate and vilanterol may weaken asthma or COPD control.
What this interaction means in plain words
Fluticasone-vilanterol and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Mitotane belongs to Oncology.
Why it happens
Induction of CYP3A4 leading to faster metabolism of fluticasone furoate and vilanterol.
What to do
Monitor respiratory symptoms and lung function and step up therapy if control worsens. Keep in mind that the induction persists after mitotane is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Mitotane?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a potent CYP3A4 inducer that can lower exposure to CYP3A4 substrates for weeks after it is stopped. Reduced levels of fluticasone furoate and vilanterol may weaken asthma or COPD control.
How serious is the interaction between Fluticasone-vilanterol and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms and lung function and step up therapy if control worsens. Keep in mind that the induction persists after mitotane is discontinued.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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