Drug interactions
Fluticasone-vilanterol + Nadolol
Severity: Major
Fluticasone-vilanterol and Nadolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a non-selective beta-blocker that blocks beta-2 receptors in the airways and can oppose the bronchodilating effect of vilanterol. In patients with COPD or asthma this may reduce bronchodilator efficacy and provoke bronchospasm.
What this interaction means in plain words
Fluticasone-vilanterol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Nadolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by a non-selective beta-blocker.
What to do
Avoid non-selective beta-blockers in patients with reactive airway disease who need vilanterol; if a beta-blocker is essential, choose a cardioselective agent at the lowest effective dose and monitor respiratory function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Nadolol
Frequently asked questions
Can I take Fluticasone-vilanterol with Nadolol?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol is a non-selective beta-blocker that blocks beta-2 receptors in the airways and can oppose the bronchodilating effect of vilanterol. In patients with COPD or asthma this may reduce bronchodilator efficacy and provoke bronchospasm.
How serious is the interaction between Fluticasone-vilanterol and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers in patients with reactive airway disease who need vilanterol; if a beta-blocker is essential, choose a cardioselective agent at the lowest effective dose and monitor respiratory function.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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