Drug interactions
Fluticasone-vilanterol + Propafenone
Severity: Moderate
Fluticasone-vilanterol and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone can prolong QRS and QT intervals and is proarrhythmic, and beta-2 agonists add tachycardia and hypokalemia. Propafenone also has beta-blocking activity that may blunt bronchodilation.
What this interaction means in plain words
Fluticasone-vilanterol and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Propafenone belongs to Cardiovascular.
Why it happens
Additive effects on cardiac conduction and repolarization, plus weak beta-blockade antagonizing beta-2 agonist effect.
What to do
Monitor ECG, electrolytes and respiratory response, especially in patients with structural heart disease or COPD.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Propafenone?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone can prolong QRS and QT intervals and is proarrhythmic, and beta-2 agonists add tachycardia and hypokalemia. Propafenone also has beta-blocking activity that may blunt bronchodilation.
How serious is the interaction between Fluticasone-vilanterol and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, electrolytes and respiratory response, especially in patients with structural heart disease or COPD.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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