Drug interactions
Fluticasone-vilanterol + Ritonavir
Severity: Major
Fluticasone-vilanterol and Ritonavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a strong CYP3A4 inhibitor and markedly raises systemic exposure to fluticasone, with reports of Cushing syndrome and adrenal suppression. It can also raise vilanterol levels, increasing tachycardia and hypokalemia.
What this interaction means in plain words
Fluticasone-vilanterol and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Ritonavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of fluticasone furoate and vilanterol.
What to do
Avoid the combination where possible and use an alternative inhaled corticosteroid such as beclometasone. If unavoidable, monitor for adrenal suppression and beta-agonist cardiovascular effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Ritonavir?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir is a strong CYP3A4 inhibitor and markedly raises systemic exposure to fluticasone, with reports of Cushing syndrome and adrenal suppression. It can also raise vilanterol levels, increasing tachycardia and hypokalemia.
How serious is the interaction between Fluticasone-vilanterol and Ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative inhaled corticosteroid such as beclometasone. If unavoidable, monitor for adrenal suppression and beta-agonist cardiovascular effects.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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