Drug interactions
Fluticasone-vilanterol + Thioridazine
Severity: Major
Fluticasone-vilanterol and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine is a potent QT-prolonging drug linked to torsades de pointes. Beta-2 agonists such as vilanterol can add to this risk through tachycardia and lowering of potassium.
What this interaction means in plain words
Fluticasone-vilanterol and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Thioridazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and proarrhythmic adrenergic effects.
What to do
Avoid the combination if possible and consider an alternative antipsychotic or bronchodilator regimen. If used together, monitor ECG and keep potassium and magnesium in the normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Thioridazine?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine is a potent QT-prolonging drug linked to torsades de pointes. Beta-2 agonists such as vilanterol can add to this risk through tachycardia and lowering of potassium.
How serious is the interaction between Fluticasone-vilanterol and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and consider an alternative antipsychotic or bronchodilator regimen. If used together, monitor ECG and keep potassium and magnesium in the normal range.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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