Drug interactions
Fluticasone-vilanterol + Tranylcypromine
Severity: Major
Fluticasone-vilanterol and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can potentiate the cardiovascular effects of beta-2 agonists, with a possible rise in blood pressure, tachycardia and arrhythmia. The effect may persist for up to two weeks after the MAOI is stopped.
What this interaction means in plain words
Fluticasone-vilanterol and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition raises catecholamine stores, and this adds to the adrenergic stimulation produced by vilanterol.
What to do
Avoid the combination where possible, including for two weeks after stopping the MAOI. If used, monitor blood pressure and heart rate closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Tranylcypromine?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors can potentiate the cardiovascular effects of beta-2 agonists, with a possible rise in blood pressure, tachycardia and arrhythmia. The effect may persist for up to two weeks after the MAOI is stopped.
How serious is the interaction between Fluticasone-vilanterol and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, including for two weeks after stopping the MAOI. If used, monitor blood pressure and heart rate closely.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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