Drug interactions
Fluticasone-vilanterol + Ziprasidone
Severity: Major
Fluticasone-vilanterol and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone prolongs the QT interval more than most antipsychotics, and vilanterol can add to arrhythmic risk through tachycardia and hypokalemia. This is relevant in patients with cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Fluticasone-vilanterol and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and adrenergic cardiac stimulation.
What to do
Avoid in patients with QT risk factors and consider an alternative antipsychotic. Otherwise monitor ECG and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Ziprasidone?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ziprasidone prolongs the QT interval more than most antipsychotics, and vilanterol can add to arrhythmic risk through tachycardia and hypokalemia. This is relevant in patients with cardiac disease or electrolyte disturbance.
How serious is the interaction between Fluticasone-vilanterol and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with QT risk factors and consider an alternative antipsychotic. Otherwise monitor ECG and keep potassium and magnesium normal.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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