Drug interactions
Fluvastatin + Fluvoxamine
Severity: Moderate
Fluvastatin and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits CYP2C9 and can raise fluvastatin levels. This may increase the risk of statin-related muscle toxicity.
What this interaction means in plain words
Fluvastatin and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Fluvoxamine belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibits CYP2C9, reducing fluvastatin clearance.
What to do
Monitor for muscle pain or weakness and consider limiting the fluvastatin dose. Check creatine kinase if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvastatin with Fluvoxamine?
MediHelp rates the interaction as moderate. Fluvastatin and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine inhibits CYP2C9 and can raise fluvastatin levels. This may increase the risk of statin-related muscle toxicity.
How serious is the interaction between Fluvastatin and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain or weakness and consider limiting the fluvastatin dose. Check creatine kinase if symptoms appear.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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