Drug interactions
Fluvastatin + Lomitapide
Severity: Minor
Fluvastatin and Lomitapide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvastatin is not a meaningful CYP3A4 inhibitor, so no relevant rise in lomitapide exposure is expected. Both drugs can raise liver enzymes, so liver tests merit attention.
What this interaction means in plain words
Fluvastatin and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
No pharmacokinetic mechanism established; additive hepatotoxicity potential.
What to do
Monitor liver enzymes as per lomitapide labeling. No dose adjustment is needed for the combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Fluvastatin with Lomitapide?
MediHelp rates the interaction as minor. Fluvastatin and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvastatin is not a meaningful CYP3A4 inhibitor, so no relevant rise in lomitapide exposure is expected. Both drugs can raise liver enzymes, so liver tests merit attention.
How serious is the interaction between Fluvastatin and Lomitapide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes as per lomitapide labeling. No dose adjustment is needed for the combination.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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