Drug interactions
Fluvastatin + Lonafarnib
Severity: Minor
Fluvastatin and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, but fluvastatin is metabolised mainly by CYP2C9 and has no meaningful CYP3A inhibitory activity. A clinically relevant rise in lonafarnib exposure is therefore not expected from fluvastatin.
What this interaction means in plain words
Fluvastatin and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Lonafarnib belongs to Miscellaneous.
Why it happens
No established mechanism; fluvastatin is not a recognised CYP3A4 inhibitor.
What to do
No dose change is needed. Monitor routinely for lonafarnib adverse effects and for statin-related muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Fluvastatin with Lonafarnib?
MediHelp rates the interaction as minor. Fluvastatin and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A substrate, but fluvastatin is metabolised mainly by CYP2C9 and has no meaningful CYP3A inhibitory activity. A clinically relevant rise in lonafarnib exposure is therefore not expected from fluvastatin.
How serious is the interaction between Fluvastatin and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor routinely for lonafarnib adverse effects and for statin-related muscle symptoms.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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