Drug interactions
Fluvastatin + Trofinetide
Severity: Moderate
Fluvastatin and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide inhibits OATP1B1 and OATP1B3 in vitro, transporters that mediate hepatic uptake of statins including fluvastatin. This could increase plasma fluvastatin concentrations and the risk of muscle toxicity.
What this interaction means in plain words
Fluvastatin and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Trofinetide inhibits OATP1B1/1B3-mediated hepatic uptake of fluvastatin.
What to do
Use the lowest effective fluvastatin dose and monitor for myalgia or weakness. Check CK if symptoms occur and consider an alternative lipid-lowering therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Trofinetide
Frequently asked questions
Can I take Fluvastatin with Trofinetide?
MediHelp rates the interaction as moderate. Fluvastatin and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide inhibits OATP1B1 and OATP1B3 in vitro, transporters that mediate hepatic uptake of statins including fluvastatin. This could increase plasma fluvastatin concentrations and the risk of muscle toxicity.
How serious is the interaction between Fluvastatin and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective fluvastatin dose and monitor for myalgia or weakness. Check CK if symptoms occur and consider an alternative lipid-lowering therapy.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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