Drug interactions
Fluvastatin + Voriconazole
Severity: Moderate
Fluvastatin and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise fluvastatin concentrations, which could increase the risk of myopathy. Fluvastatin is cleared mainly by CYP2C9, which voriconazole inhibits.
What this interaction means in plain words
Fluvastatin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP2C9-mediated fluvastatin metabolism by voriconazole.
What to do
Consider a lower fluvastatin dose and counsel the patient to report muscle pain or weakness. Check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Voriconazole?
MediHelp rates the interaction as moderate. Fluvastatin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may raise fluvastatin concentrations, which could increase the risk of myopathy. Fluvastatin is cleared mainly by CYP2C9, which voriconazole inhibits.
How serious is the interaction between Fluvastatin and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower fluvastatin dose and counsel the patient to report muscle pain or weakness. Check CK if symptoms occur.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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