Drug interactions
Fluvoxamine + Frovatriptan
Severity: Moderate
Fluvoxamine and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a triptan with an SSRI may add serotonergic stimulation and rarely cause serotonin syndrome. Fluvoxamine inhibits CYP1A2, which is involved in frovatriptan clearance, so triptan levels may also rise.
What this interaction means in plain words
Fluvoxamine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Frovatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects, plus fluvoxamine inhibition of CYP1A2-mediated frovatriptan metabolism.
What to do
Monitor for features of serotonin toxicity, particularly when starting or increasing either drug. Avoid exceeding the recommended frovatriptan dose and stop it if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Frovatriptan?
MediHelp rates the interaction as moderate. Fluvoxamine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a triptan with an SSRI may add serotonergic stimulation and rarely cause serotonin syndrome. Fluvoxamine inhibits CYP1A2, which is involved in frovatriptan clearance, so triptan levels may also rise.
How serious is the interaction between Fluvoxamine and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for features of serotonin toxicity, particularly when starting or increasing either drug. Avoid exceeding the recommended frovatriptan dose and stop it if symptoms appear.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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