Drug interactions
Fluvoxamine + Givinostat
Severity: Moderate
Fluvoxamine and Givinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT interval prolongation. Taken together they may increase the risk of ventricular arrhythmias, especially with electrolyte abnormalities or heart disease.
What this interaction means in plain words
Fluvoxamine and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Why it happens
Additive effects on cardiac repolarization (QTc prolongation).
What to do
Obtain an ECG at baseline and during concurrent use, and correct potassium and magnesium abnormalities. Withhold givinostat if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Fluvoxamine with Givinostat?
MediHelp rates the interaction as moderate. Fluvoxamine and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT interval prolongation. Taken together they may increase the risk of ventricular arrhythmias, especially with electrolyte abnormalities or heart disease.
How serious is the interaction between Fluvoxamine and Givinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and during concurrent use, and correct potassium and magnesium abnormalities. Withhold givinostat if the QTc becomes markedly prolonged.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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