Drug interactions
Fluvoxamine + Glyburide-metformin
Severity: Moderate
Fluvoxamine and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine may potentiate the glucose-lowering effect of antidiabetic drugs and cases of hypoglycemia have been reported. Fluvoxamine also inhibits CYP2C9 and may raise glyburide levels.
What this interaction means in plain words
Fluvoxamine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Glyburide-metformin belongs to Endocrine.
Why it happens
Additive glucose lowering plus CYP2C9 inhibition by fluvoxamine reducing glyburide clearance.
What to do
Monitor blood glucose when fluvoxamine is started or stopped. Reduce the sulfonylurea dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Glyburide-metformin?
MediHelp rates the interaction as moderate. Fluvoxamine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine may potentiate the glucose-lowering effect of antidiabetic drugs and cases of hypoglycemia have been reported. Fluvoxamine also inhibits CYP2C9 and may raise glyburide levels.
How serious is the interaction between Fluvoxamine and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fluvoxamine is started or stopped. Reduce the sulfonylurea dose if hypoglycemia develops.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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