Drug interactions
Fluvoxamine + Ifosfamide
Severity: Minor
Fluvoxamine and Ifosfamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is a prodrug activated partly by CYP2B6 and CYP3A4. Fluvoxamine may inhibit CYP2B6 modestly, which could reduce formation of active metabolites, though clinical significance is uncertain.
What this interaction means in plain words
Fluvoxamine and Ifosfamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Ifosfamide belongs to Oncology.
Why it happens
Possible inhibition of CYP2B6-mediated bioactivation of ifosfamide by fluvoxamine.
What to do
No routine change is needed; monitor oncologic response and toxicity. Consider an alternative antidepressant if loss of efficacy is a concern.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Ifosfamide?
MediHelp rates the interaction as minor. Fluvoxamine and Ifosfamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ifosfamide is a prodrug activated partly by CYP2B6 and CYP3A4. Fluvoxamine may inhibit CYP2B6 modestly, which could reduce formation of active metabolites, though clinical significance is uncertain.
How serious is the interaction between Fluvoxamine and Ifosfamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor oncologic response and toxicity. Consider an alternative antidepressant if loss of efficacy is a concern.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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