Drug interactions
Fluvoxamine + Irinotecan
Severity: Minor
Fluvoxamine and Irinotecan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan is mainly activated by carboxylesterases and inactivated via CYP3A4 and UGT1A1. Fluvoxamine has a weak effect on CYP3A4 and no clearly established effect on irinotecan, so a clinically relevant interaction is not well documented.
What this interaction means in plain words
Fluvoxamine and Irinotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Irinotecan belongs to Oncology.
Why it happens
Theoretical minor CYP inhibition by fluvoxamine; mechanism not firmly established.
What to do
No adjustment is required. Monitor for diarrhea and neutropenia as usual during irinotecan therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Fluvoxamine with Irinotecan?
MediHelp rates the interaction as minor. Fluvoxamine and Irinotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Irinotecan is mainly activated by carboxylesterases and inactivated via CYP3A4 and UGT1A1. Fluvoxamine has a weak effect on CYP3A4 and no clearly established effect on irinotecan, so a clinically relevant interaction is not well documented.
How serious is the interaction between Fluvoxamine and Irinotecan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required. Monitor for diarrhea and neutropenia as usual during irinotecan therapy.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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