Drug interactions
Fluvoxamine + Isoflurane
Severity: Minor
Fluvoxamine and Isoflurane: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval, and fluvoxamine may add a small effect. The clinical significance is likely low and the evidence is largely theoretical.
What this interaction means in plain words
Fluvoxamine and Isoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Isoflurane belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation; mechanism of interaction not firmly established.
What to do
Inform the anesthesia team and monitor ECG perioperatively, keeping potassium and magnesium normal.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Fluvoxamine with Isoflurane?
MediHelp rates the interaction as minor. Fluvoxamine and Isoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoflurane can prolong the QT interval, and fluvoxamine may add a small effect. The clinical significance is likely low and the evidence is largely theoretical.
How serious is the interaction between Fluvoxamine and Isoflurane?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and monitor ECG perioperatively, keeping potassium and magnesium normal.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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