Drug interactions
Fluvoxamine + Ivosidenib
Severity: Moderate
Fluvoxamine and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is metabolized by CYP3A4 and can prolong the QT interval. Fluvoxamine may raise ivosidenib exposure and also has some QT liability, so the arrhythmia risk is increased.
What this interaction means in plain words
Fluvoxamine and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Ivosidenib belongs to Oncology.
Why it happens
CYP3A4 inhibition by fluvoxamine raises ivosidenib levels, with additive QT prolongation.
What to do
Monitor ECG and electrolytes, and consider an alternative to fluvoxamine if the QTc increases. Reduce the ivosidenib dose per labeling if a strong CYP3A4 inhibitor is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvoxamine and Ivosidenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Fluvoxamine with Ivosidenib?
MediHelp rates the interaction as moderate. Fluvoxamine and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib is metabolized by CYP3A4 and can prolong the QT interval. Fluvoxamine may raise ivosidenib exposure and also has some QT liability, so the arrhythmia risk is increased.
How serious is the interaction between Fluvoxamine and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and consider an alternative to fluvoxamine if the QTc increases. Reduce the ivosidenib dose per labeling if a strong CYP3A4 inhibitor is needed.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
