Drug interactions
Fluvoxamine + Lumateperone
Severity: Moderate
Fluvoxamine and Lumateperone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumateperone is metabolized by CYP3A4, and fluvoxamine can increase its exposure. Higher levels may cause more sedation, orthostatic hypotension and other adverse effects.
What this interaction means in plain words
Fluvoxamine and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Lumateperone belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibits CYP3A4, reducing lumateperone clearance.
What to do
Reduce the lumateperone dose to 21 mg daily as per labeling for moderate CYP3A4 inhibitors. Monitor for sedation and blood pressure changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Lumateperone
Frequently asked questions
Can I take Fluvoxamine with Lumateperone?
MediHelp rates the interaction as moderate. Fluvoxamine and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumateperone is metabolized by CYP3A4, and fluvoxamine can increase its exposure. Higher levels may cause more sedation, orthostatic hypotension and other adverse effects.
How serious is the interaction between Fluvoxamine and Lumateperone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the lumateperone dose to 21 mg daily as per labeling for moderate CYP3A4 inhibitors. Monitor for sedation and blood pressure changes.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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