Drug interactions
Fluvoxamine + Meloxicam
Severity: Moderate
Fluvoxamine and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine combined with an NSAID increases the risk of bleeding, particularly upper GI bleeding. Fluvoxamine also inhibits CYP2C9 to some extent, which may raise meloxicam exposure.
What this interaction means in plain words
Fluvoxamine and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Meloxicam belongs to Musculoskeletal.
Why it happens
SSRI-induced platelet serotonin depletion adds to NSAID antiplatelet and mucosal effects; possible CYP2C9 inhibition.
What to do
Consider gastroprotection with a proton pump inhibitor in at-risk patients and use the lowest effective meloxicam dose. Monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Meloxicam?
MediHelp rates the interaction as moderate. Fluvoxamine and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine combined with an NSAID increases the risk of bleeding, particularly upper GI bleeding. Fluvoxamine also inhibits CYP2C9 to some extent, which may raise meloxicam exposure.
How serious is the interaction between Fluvoxamine and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor in at-risk patients and use the lowest effective meloxicam dose. Monitor for signs of GI bleeding.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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