Drug interactions
Fluvoxamine + Metformin-pioglitazone
Severity: Minor
Fluvoxamine and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine may enhance glucose lowering and hypoglycemia has been reported with antidiabetic drugs. It is also a potent CYP1A2 and CYP2C19 inhibitor, and a modest effect on pioglitazone is possible through CYP2C8 and CYP3A4 pathways.
What this interaction means in plain words
Fluvoxamine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Serotonergic effects on glucose regulation, with possible minor inhibition of pioglitazone metabolism.
What to do
Monitor blood glucose when starting or stopping fluvoxamine and adjust antidiabetic doses if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Fluvoxamine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine may enhance glucose lowering and hypoglycemia has been reported with antidiabetic drugs. It is also a potent CYP1A2 and CYP2C19 inhibitor, and a modest effect on pioglitazone is possible through CYP2C8 and CYP3A4 pathways.
How serious is the interaction between Fluvoxamine and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fluvoxamine and adjust antidiabetic doses if needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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