Drug interactions
Fluvoxamine + Metformin-repaglinide
Severity: Moderate
Fluvoxamine and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits several CYP enzymes and can increase repaglinide exposure, raising hypoglycemia risk. SSRIs may also independently enhance glucose lowering.
What this interaction means in plain words
Fluvoxamine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Metformin-repaglinide belongs to Endocrine.
Why it happens
CYP inhibition reducing repaglinide metabolism, plus additive glucose-lowering effects.
What to do
Monitor blood glucose closely when fluvoxamine is started or stopped and reduce repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Fluvoxamine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine inhibits several CYP enzymes and can increase repaglinide exposure, raising hypoglycemia risk. SSRIs may also independently enhance glucose lowering.
How serious is the interaction between Fluvoxamine and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when fluvoxamine is started or stopped and reduce repaglinide dose if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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