Drug interactions
Fluvoxamine + Nelfinavir
Severity: Minor
Fluvoxamine and Nelfinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine may modestly increase nelfinavir concentrations through CYP3A4 inhibition, though nelfinavir is also cleared by CYP2C19 and other routes. The clinical effect is usually limited, but higher exposure may increase gastrointestinal toxicity.
What this interaction means in plain words
Fluvoxamine and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Nelfinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 (and possibly CYP2C19) metabolism of nelfinavir by fluvoxamine.
What to do
Monitor for nelfinavir adverse effects such as diarrhea and consider checking antiretroviral tolerability; no routine dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Nelfinavir?
MediHelp rates the interaction as minor. Fluvoxamine and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine may modestly increase nelfinavir concentrations through CYP3A4 inhibition, though nelfinavir is also cleared by CYP2C19 and other routes. The clinical effect is usually limited, but higher exposure may increase gastrointestinal toxicity.
How serious is the interaction between Fluvoxamine and Nelfinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nelfinavir adverse effects such as diarrhea and consider checking antiretroviral tolerability; no routine dose change is required.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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