Drug interactions
Fluvoxamine + Nifedipine
Severity: Moderate
Fluvoxamine and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine can increase nifedipine exposure, with a risk of hypotension, headache, flushing and peripheral edema. The effect varies between patients.
What this interaction means in plain words
Fluvoxamine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Nifedipine belongs to Cardiovascular.
Why it happens
Fluvoxamine inhibits CYP3A4, reducing nifedipine metabolism.
What to do
Monitor blood pressure and heart rate when starting or stopping fluvoxamine, and reduce the nifedipine dose if hypotension or adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Nifedipine?
MediHelp rates the interaction as moderate. Fluvoxamine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine can increase nifedipine exposure, with a risk of hypotension, headache, flushing and peripheral edema. The effect varies between patients.
How serious is the interaction between Fluvoxamine and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping fluvoxamine, and reduce the nifedipine dose if hypotension or adverse effects occur.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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