Drug interactions
Fluvoxamine + Nilotinib
Severity: Major
Fluvoxamine and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib prolongs the QT interval and is a CYP3A4 substrate. Fluvoxamine may increase nilotinib exposure through weak CYP3A4 inhibition and has its own QT effects, raising arrhythmia risk.
What this interaction means in plain words
Fluvoxamine and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by fluvoxamine raising nilotinib levels.
What to do
Avoid if possible; otherwise obtain baseline and follow-up ECGs and keep potassium and magnesium normal. Choose an antidepressant with lower QT and CYP3A4 effects such as sertraline.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Nilotinib?
MediHelp rates the interaction as major. Fluvoxamine and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib prolongs the QT interval and is a CYP3A4 substrate. Fluvoxamine may increase nilotinib exposure through weak CYP3A4 inhibition and has its own QT effects, raising arrhythmia risk.
How serious is the interaction between Fluvoxamine and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain baseline and follow-up ECGs and keep potassium and magnesium normal. Choose an antidepressant with lower QT and CYP3A4 effects such as sertraline.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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