Drug interactions
Fluvoxamine + Norgestrel
Severity: Minor
Fluvoxamine and Norgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine may increase systemic levels of norgestrel via CYP3A4 inhibition. The effect is probably small, with possible increases in progestogenic adverse effects such as breast tenderness, nausea or spotting; contraceptive efficacy is not reduced.
What this interaction means in plain words
Fluvoxamine and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Norgestrel belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 metabolism of norgestrel by fluvoxamine.
What to do
No routine action is needed; ask about hormonal adverse effects and review the contraceptive if they persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Fluvoxamine with Norgestrel?
MediHelp rates the interaction as minor. Fluvoxamine and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine may increase systemic levels of norgestrel via CYP3A4 inhibition. The effect is probably small, with possible increases in progestogenic adverse effects such as breast tenderness, nausea or spotting; contraceptive efficacy is not reduced.
How serious is the interaction between Fluvoxamine and Norgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; ask about hormonal adverse effects and review the contraceptive if they persist.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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