Drug interactions
Fluvoxamine + Palovarotene
Severity: Major
Fluvoxamine and Palovarotene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palovarotene is cleared by CYP3A4, and fluvoxamine as a moderate inhibitor can increase its exposure. This may heighten retinoid toxicities such as mucocutaneous effects, premature epiphyseal closure and bone changes.
What this interaction means in plain words
Fluvoxamine and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Palovarotene belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 reduces palovarotene metabolism.
What to do
Avoid combining if possible; if unavoidable, reduce the palovarotene dose by 50% per labeling. Monitor for retinoid adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Fluvoxamine with Palovarotene?
MediHelp rates the interaction as major. Fluvoxamine and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palovarotene is cleared by CYP3A4, and fluvoxamine as a moderate inhibitor can increase its exposure. This may heighten retinoid toxicities such as mucocutaneous effects, premature epiphyseal closure and bone changes.
How serious is the interaction between Fluvoxamine and Palovarotene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible; if unavoidable, reduce the palovarotene dose by 50% per labeling. Monitor for retinoid adverse effects.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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