Drug interactions
Fluvoxamine + Pazopanib
Severity: Moderate
Fluvoxamine and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is metabolized mainly by CYP3A4, and fluvoxamine is a weak to moderate inhibitor that may raise its exposure. Pazopanib itself causes QT prolongation and hepatotoxicity, so higher levels are undesirable.
What this interaction means in plain words
Fluvoxamine and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
CYP3A4 inhibition by fluvoxamine reduces pazopanib clearance, with additive QT effects.
What to do
Monitor liver function and ECG, and reduce the pazopanib dose if toxicity occurs. Consider an alternative antidepressant with less CYP inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Fluvoxamine with Pazopanib?
MediHelp rates the interaction as moderate. Fluvoxamine and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib is metabolized mainly by CYP3A4, and fluvoxamine is a weak to moderate inhibitor that may raise its exposure. Pazopanib itself causes QT prolongation and hepatotoxicity, so higher levels are undesirable.
How serious is the interaction between Fluvoxamine and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function and ECG, and reduce the pazopanib dose if toxicity occurs. Consider an alternative antidepressant with less CYP inhibition.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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