Drug interactions
Fluvoxamine + Repaglinide
Severity: Moderate
Fluvoxamine and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is cleared by CYP2C8 and CYP3A4, and fluvoxamine's weak CYP3A4 inhibition may modestly raise exposure. This could increase the chance of hypoglycemia.
What this interaction means in plain words
Fluvoxamine and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Repaglinide belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition by fluvoxamine reduces repaglinide metabolism.
What to do
Monitor blood glucose when starting or stopping fluvoxamine. Reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Fluvoxamine with Repaglinide?
MediHelp rates the interaction as moderate. Fluvoxamine and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repaglinide is cleared by CYP2C8 and CYP3A4, and fluvoxamine's weak CYP3A4 inhibition may modestly raise exposure. This could increase the chance of hypoglycemia.
How serious is the interaction between Fluvoxamine and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fluvoxamine. Reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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