Drug interactions
Fluvoxamine + Safinamide
Severity: Major
Fluvoxamine and Safinamide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide is an MAO-B inhibitor, and combination with SSRIs may increase the risk of serotonin syndrome. Labeling advises caution and the lowest effective doses.
What this interaction means in plain words
Fluvoxamine and Safinamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from MAO-B inhibition and serotonin reuptake inhibition.
What to do
Avoid if possible, otherwise use the lowest effective doses and monitor for agitation, tremor, hyperthermia and clonus. Stop both agents if serotonin syndrome occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Safinamide?
MediHelp rates the interaction as major. Fluvoxamine and Safinamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Safinamide is an MAO-B inhibitor, and combination with SSRIs may increase the risk of serotonin syndrome. Labeling advises caution and the lowest effective doses.
How serious is the interaction between Fluvoxamine and Safinamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, otherwise use the lowest effective doses and monitor for agitation, tremor, hyperthermia and clonus. Stop both agents if serotonin syndrome occurs.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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