Drug interactions
Fluvoxamine + Somapacitan
Severity: Minor
Fluvoxamine and Somapacitan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone can increase the activity of some CYP enzymes, including CYP1A2, and may lower concentrations of sensitive substrates. Fluvoxamine is partly cleared by CYP1A2 and CYP2D6, so reduced effect is possible but likely small.
What this interaction means in plain words
Fluvoxamine and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Somapacitan belongs to Endocrine.
Why it happens
Possible induction of CYP-mediated clearance by growth hormone therapy.
What to do
Monitor antidepressant response when somapacitan is started or the dose changed; adjust fluvoxamine only if symptoms recur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Fluvoxamine with Somapacitan?
MediHelp rates the interaction as minor. Fluvoxamine and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone can increase the activity of some CYP enzymes, including CYP1A2, and may lower concentrations of sensitive substrates. Fluvoxamine is partly cleared by CYP1A2 and CYP2D6, so reduced effect is possible but likely small.
How serious is the interaction between Fluvoxamine and Somapacitan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response when somapacitan is started or the dose changed; adjust fluvoxamine only if symptoms recur.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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