Drug interactions
Fluvoxamine + Sunitinib
Severity: Moderate
Fluvoxamine and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib can prolong the QT interval and is metabolized by CYP3A4, which fluvoxamine weakly inhibits. Combined use may raise sunitinib exposure and arrhythmia risk.
What this interaction means in plain words
Fluvoxamine and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Sunitinib belongs to Oncology.
Why it happens
Additive QT prolongation with weak CYP3A4 inhibition by fluvoxamine increasing sunitinib levels.
What to do
Obtain a baseline ECG and electrolytes and monitor QTc during therapy. Consider an antidepressant with less QT and CYP3A4 effect if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Fluvoxamine with Sunitinib?
MediHelp rates the interaction as moderate. Fluvoxamine and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib can prolong the QT interval and is metabolized by CYP3A4, which fluvoxamine weakly inhibits. Combined use may raise sunitinib exposure and arrhythmia risk.
How serious is the interaction between Fluvoxamine and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and monitor QTc during therapy. Consider an antidepressant with less QT and CYP3A4 effect if QTc lengthens.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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