Drug interactions
Fluvoxamine + Zuranolone
Severity: Moderate
Fluvoxamine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes dose-related sedation and impaired psychomotor performance, which may be intensified by other CNS-active drugs. Fluvoxamine's CYP3A4 inhibition may also raise zuranolone concentrations.
What this interaction means in plain words
Fluvoxamine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus possible increased zuranolone exposure through fluvoxamine's inhibition of CYP3A4.
What to do
Counsel patients about drowsiness and avoid driving for at least 12 hours after each zuranolone dose. Reduce the zuranolone dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Fluvoxamine with Zuranolone?
MediHelp rates the interaction as moderate. Fluvoxamine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes dose-related sedation and impaired psychomotor performance, which may be intensified by other CNS-active drugs. Fluvoxamine's CYP3A4 inhibition may also raise zuranolone concentrations.
How serious is the interaction between Fluvoxamine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and avoid driving for at least 12 hours after each zuranolone dose. Reduce the zuranolone dose if excessive sedation occurs.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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