Drug interactions
Folic acid + Linagliptin-metformin
Severity: Minor
Folic acid and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term metformin use is associated with reduced vitamin B12 absorption, and some reports suggest it may lower folate status. Folic acid supplementation can mask the hematologic signs of B12 deficiency while neurologic damage progresses.
What this interaction means in plain words
Folic acid and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Folic acid belongs to Miscellaneous; Linagliptin-metformin belongs to Endocrine.
Why it happens
The mechanism for any effect on folate is not well established; metformin impairs calcium-dependent B12 absorption in the ileum.
What to do
Check vitamin B12 periodically in long-term metformin users, particularly if folic acid is supplemented or anemia or neuropathy develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Folic acid with Linagliptin-metformin?
MediHelp rates the interaction as minor. Folic acid and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term metformin use is associated with reduced vitamin B12 absorption, and some reports suggest it may lower folate status. Folic acid supplementation can mask the hematologic signs of B12 deficiency while neurologic damage progresses.
How serious is the interaction between Folic acid and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check vitamin B12 periodically in long-term metformin users, particularly if folic acid is supplemented or anemia or neuropathy develops.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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