Drug interactions
Folic acid + Saxagliptin-metformin
Severity: Minor
Folic acid and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin has been associated with lower folate levels, possibly linked to impaired B12 status. Folic acid supplementation can correct low levels, and folate may mask B12 deficiency anemia.
What this interaction means in plain words
Folic acid and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Folic acid belongs to Miscellaneous; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Metformin may interfere with intestinal absorption of folate; the mechanism is not firmly established.
What to do
Check B12 along with folate in long-term metformin users and supplement as indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Folic acid with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Folic acid and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metformin has been associated with lower folate levels, possibly linked to impaired B12 status. Folic acid supplementation can correct low levels, and folate may mask B12 deficiency anemia.
How serious is the interaction between Folic acid and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check B12 along with folate in long-term metformin users and supplement as indicated.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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