Drug interactions
Fondaparinux + Quinine
Severity: Moderate
Fondaparinux and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine can occasionally cause immune thrombocytopenia and bleeding, which may add to the hemorrhagic risk of fondaparinux. No direct interaction between the two has been clearly established.
What this interaction means in plain words
Fondaparinux and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fondaparinux belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Additive bleeding risk through quinine-associated thrombocytopenia; no established pharmacokinetic mechanism.
What to do
Monitor platelet count and bleeding signs during combined use. Discontinue quinine if thrombocytopenia or bleeding develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Fondaparinux with Quinine?
MediHelp rates the interaction as moderate. Fondaparinux and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine can occasionally cause immune thrombocytopenia and bleeding, which may add to the hemorrhagic risk of fondaparinux. No direct interaction between the two has been clearly established.
How serious is the interaction between Fondaparinux and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet count and bleeding signs during combined use. Discontinue quinine if thrombocytopenia or bleeding develops.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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