Drug interactions
Formoterol + Gepirone
Severity: Moderate
Formoterol and Gepirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone carries a QT prolongation warning, and formoterol can cause tachycardia, hypokalemia and QT prolongation. Combined use may increase the risk of ventricular arrhythmias, especially in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Formoterol and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol belongs to Respiratory; Gepirone belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with formoterol-induced hypokalemia further increasing arrhythmia risk.
What to do
Check ECG and electrolytes at baseline in patients with cardiac risk factors and correct low potassium or magnesium. Monitor for palpitations or syncope and reassess therapy if QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Formoterol with Gepirone?
MediHelp rates the interaction as moderate. Formoterol and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gepirone carries a QT prolongation warning, and formoterol can cause tachycardia, hypokalemia and QT prolongation. Combined use may increase the risk of ventricular arrhythmias, especially in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Formoterol and Gepirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline in patients with cardiac risk factors and correct low potassium or magnesium. Monitor for palpitations or syncope and reassess therapy if QTc lengthens significantly.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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