Drug interactions
Formoterol + Midodrine
Severity: Moderate
Formoterol and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist that raises blood pressure, and combining it with formoterol may add to cardiovascular stimulation, including higher blood pressure and heart rate or palpitations. The risk is greatest in patients with hypertension or arrhythmias.
What this interaction means in plain words
Formoterol and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol belongs to Respiratory; Midodrine belongs to Miscellaneous.
Why it happens
Additive adrenergic effects from alpha-1 agonism and beta-2 agonism with cardiovascular activity.
What to do
Monitor blood pressure, including supine readings, and heart rate. Adjust doses if hypertension or tachyarrhythmia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Formoterol with Midodrine?
MediHelp rates the interaction as moderate. Formoterol and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine is an alpha-1 agonist that raises blood pressure, and combining it with formoterol may add to cardiovascular stimulation, including higher blood pressure and heart rate or palpitations. The risk is greatest in patients with hypertension or arrhythmias.
How serious is the interaction between Formoterol and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, and heart rate. Adjust doses if hypertension or tachyarrhythmia develops.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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