Drug interactions
Formoterol + Tiotropium-olodaterol
Severity: Major
Formoterol and Tiotropium-olodaterol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol is another long-acting beta2 agonist, so combining it with olodaterol duplicates therapy. This increases the risk of tachycardia, tremor, hypokalemia and arrhythmia without clear added benefit.
What this interaction means in plain words
Formoterol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Formoterol belongs to Respiratory; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Duplicate beta2-adrenergic receptor agonism.
What to do
Avoid using two long-acting beta2 agonists together and choose a single agent. If the combination occurs, monitor heart rate and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tiotropium-olodaterol
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Formoterol with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Formoterol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Formoterol is another long-acting beta2 agonist, so combining it with olodaterol duplicates therapy. This increases the risk of tachycardia, tremor, hypokalemia and arrhythmia without clear added benefit.
How serious is the interaction between Formoterol and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two long-acting beta2 agonists together and choose a single agent. If the combination occurs, monitor heart rate and potassium.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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