Drug interactions
Formoterol-mometasone + Histrelin
Severity: Moderate
Formoterol-mometasone and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation, and formoterol can also affect QTc. Combined use may increase the risk of torsades de pointes in predisposed patients.
What this interaction means in plain words
Formoterol-mometasone and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation, with androgen deprivation therapy affecting cardiac repolarization.
What to do
Assess baseline QTc and electrolytes and monitor ECG in patients with cardiac risk factors. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Formoterol-mometasone with Histrelin?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation, and formoterol can also affect QTc. Combined use may increase the risk of torsades de pointes in predisposed patients.
How serious is the interaction between Formoterol-mometasone and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess baseline QTc and electrolytes and monitor ECG in patients with cardiac risk factors. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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