Drug interactions
Formoterol-mometasone + Maprotiline
Severity: Major
Formoterol-mometasone and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline can prolong QT and lower the seizure threshold, and tricyclic-type antidepressants may potentiate cardiovascular effects of beta-2 agonists. The combination can increase the risk of arrhythmia and tachycardia.
What this interaction means in plain words
Formoterol-mometasone and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Formoterol-mometasone belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive QT prolongation and potentiation of adrenergic cardiovascular effects by reuptake inhibition.
What to do
Monitor ECG, heart rate and potassium, and consider an alternative antidepressant in patients with cardiac risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Formoterol-mometasone
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Formoterol-mometasone with Maprotiline?
MediHelp rates the interaction as major. Formoterol-mometasone and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Maprotiline can prolong QT and lower the seizure threshold, and tricyclic-type antidepressants may potentiate cardiovascular effects of beta-2 agonists. The combination can increase the risk of arrhythmia and tachycardia.
How serious is the interaction between Formoterol-mometasone and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and potassium, and consider an alternative antidepressant in patients with cardiac risk factors.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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