Drug interactions
Formoterol-mometasone + Mifepristone
Severity: Major
Formoterol-mometasone and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, particularly at the higher doses used for Cushing syndrome, prolongs the QT interval and can cause hypokalemia. Formoterol adds to QT prolongation and potassium lowering, raising arrhythmia risk.
What this interaction means in plain words
Formoterol-mometasone and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Formoterol-mometasone belongs to Respiratory; Mifepristone belongs to Endocrine.
Why it happens
Additive QT prolongation, with mifepristone-related and beta2-agonist-induced hypokalemia.
What to do
Use an alternative bronchodilator when possible. If co-use is necessary, correct potassium beforehand and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Formoterol-mometasone
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Formoterol-mometasone with Mifepristone?
MediHelp rates the interaction as major. Formoterol-mometasone and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone, particularly at the higher doses used for Cushing syndrome, prolongs the QT interval and can cause hypokalemia. Formoterol adds to QT prolongation and potassium lowering, raising arrhythmia risk.
How serious is the interaction between Formoterol-mometasone and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative bronchodilator when possible. If co-use is necessary, correct potassium beforehand and monitor ECG and electrolytes.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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