Drug interactions
Formoterol-mometasone + Nadolol
Severity: Major
Formoterol-mometasone and Nadolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a nonselective beta-blocker that directly blocks the effect of formoterol and may precipitate bronchospasm in patients with asthma or COPD. This can reduce the bronchodilator benefit and worsen airway obstruction.
What this interaction means in plain words
Formoterol-mometasone and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Formoterol-mometasone belongs to Respiratory; Nadolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta2-adrenoceptors by nonselective beta-blockade.
What to do
Avoid nadolol in patients with asthma or significant COPD and choose a cardioselective beta-blocker or alternative class if a beta-blocker is needed. If unavoidable, monitor respiratory status closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Formoterol-mometasone
Other interactions of Nadolol
Frequently asked questions
Can I take Formoterol-mometasone with Nadolol?
MediHelp rates the interaction as major. Formoterol-mometasone and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol is a nonselective beta-blocker that directly blocks the effect of formoterol and may precipitate bronchospasm in patients with asthma or COPD. This can reduce the bronchodilator benefit and worsen airway obstruction.
How serious is the interaction between Formoterol-mometasone and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nadolol in patients with asthma or significant COPD and choose a cardioselective beta-blocker or alternative class if a beta-blocker is needed. If unavoidable, monitor respiratory status closely.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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