Drug interactions
Formoterol-mometasone + Ziprasidone
Severity: Major
Formoterol-mometasone and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone has a notable QT-prolonging effect and formoterol may add to it while lowering potassium. This raises the risk of torsades de pointes.
What this interaction means in plain words
Formoterol-mometasone and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Formoterol-mometasone belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation with beta-2 agonist induced hypokalemia.
What to do
Avoid if possible in patients with other QT risk factors; otherwise obtain ECG and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Formoterol-mometasone
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Formoterol-mometasone with Ziprasidone?
MediHelp rates the interaction as major. Formoterol-mometasone and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ziprasidone has a notable QT-prolonging effect and formoterol may add to it while lowering potassium. This raises the risk of torsades de pointes.
How serious is the interaction between Formoterol-mometasone and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible in patients with other QT risk factors; otherwise obtain ECG and keep potassium and magnesium normal.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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